Treatment of Genetic Disorders Before Birth

Doctors may one day be able to cope with genetic blood diseases before a child born even. In a study on mice published this week in the Journal of Clinical Investigation, researchers at the University of California, San Francisco, found that transplanting fills her mother’s own stem cells into the fetal bone marrow with healthy cells while avoiding immune rejection.

If these results could true in humans, stem cell transplantation from mother to fetus primarily fetal bone-marrow transplant from her mother or a donor, a tissue-matched to the mother after birth.

It can, for example chorráncheallach Disease and beta thalassemia anemia due to abnormal red blood cells and bone marrow transplantation treated with transplantation. But still can not find a match. And need bone marrow transplants standard even between tissue-matched donors, to be followed by the long course of immunosuppressive drugs.

Researchers theorize that occur when fetal bone marrow transplants still under development that would overcome this problem. They suspected that the immature fetal immune system can be tricked to accept the foreign cells and identify them as his own. “The fetal cells are wired to tolerate, when he encounters the mother cells, tolerate them,” says Tippi MacKenzie, the pediatric surgeon at UCSF who led the new research.
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Animal research has shown that the promise of this approach. But early tests in humans came up against a big step back rejected donor cells and fetus were killed before they can get, and nobody was quite sure why. “It’s a conundrum,” says MacKenzie.

Can be blamed, it seems, mothers. MacKenzie and her colleagues found that when injected in blood-forming fetal stem cells (to populate the bone marrow and the rise to blood cells) is not matched with the mother or fetus, the infusion by influx of maternal immune cells in the fetus.